Family carers of individual’s living with Huntington’s Disease (HD) manage a distinct and unique series of difficulties arising from the complex nature of HD. This paper presents the validation of the definitive measure of quality of life for this group. The Huntington’s Disease Quality of Life Battery for carers (HDQoL-C) was expanded and then administered to an international sample of 1716 partners and family carers from 13 countries. In terms of the psychometric properties of the tool, exploratory analysis of half (...) of the sample, demonstrated good internal consistency and reliability. Some items on the full version did not meet psychometric thresholds and a short version (HDQoL-Cs) was developed based on more stringent criteria. Confirmatory Factor Analysis of the model structure showed a good fit for all Factors and, indicated that the HDQoL-C and HDQoL-Cs are psychometrically robust measures of quality of life. We found that carers who lived with and looked after their spouse/partner had reduced sense of coping, hope for the future and overall quality of life. Carers with children who were at risk, carried the gene or were symptomatic also had poorer quality of life outcomes. Findings indicated the HDQoL-C and HDQoL-Cs are valid in multiple languages and across varied cultures as measures of self-reported quality of life in family carers of individual’s living with HD. These psychometrically validated tools can aid and guide the implementation of therapeutic interventions to improve life quality in this population. (shrink)

Emotional stimuli (e.g. words, images) are often remembered better than neutral stimuli. However, little is known about how memory is affected by an environmentally induced emotional state (without any overtly emotional occurrences) – the focus of this study. Participants were randomly assigned to discovery (n = 305) and replication (n = 306) subsamples and viewed a desktop virtual environment before rating their emotions and completing objective (i.e. item, temporal-order, duration) and subjective (e.g. vividness, sensory detail, coherence) memory measures. In both (...) samples, a Partial Least Squares Correlation analysis showed that an emotional state characterised by high negative emotion (i.e. threat, fear, anxiety) and arousal was reliably associated with better memory in both objective (i.e. item) and subjective (i.e. vividness and sensory detail) domains. No reliable associations were observed for any temporal memory measures (objective or subjective). Thus, an environmentally induced state of negative emotion corresponds with enhanced memory for indices of episodic memory pertaining to “what” happened, but not necessarily “when” it happened. (shrink)

The clinical introduction of medical devices often occurs with relatively little oversight, regulation and (long-term) follow-up. Some recent controversies underscore the weaknesses of the current regime, such as the complications surrounding the metal-on-metal hip implants and the scandal surrounding the global breast implant scare of silicone implants made by France's Poly Implant Prothese (PIP) Company. The absence of national registries hampered the collection of reliable information on the risks and harms of the PIP breast implants. To warrant long-term safety, a (...) case can be made for mandatory post-marketing surveillance by means of the establishment of compulsory registries. In this edition of Public Health Ethics, Schofield calls for debate on how such a registry system should be initiated and maintained and how it would relate to the ethical requirement of consent. Here we use breast implant registries as a case to discuss whether and when a so-called ‘thick opt-out’ would be an appropriate method to include people in medical device registries. We conclude that a thick opt-out procedure for medical device registries is only justifiable in cases where inclusion does not involve burdens (or very low), when it does not involve a sensitive subject and when the data are stored anonymously (or at least not directly linked to the medical record). Otherwise, inclusion should be sought by means of an opt-in. (shrink)

All recent memory theories of hippocampal function have incorporated the idea that the hippocampus is required to process items only of some qualitatively specifiahle kind, and is not required to process items of some complementary set. In contrast, it is now proposed that the hippocampus is needed to process stimuli of all kinds, but only when there is a need to associate those stimuli with other events that are temporally discontiguous. In order to form or use temporally discontiguous associations, it (...) is essential to maintain some memory of the first component until the second component has occurred. When the temporal gap to he spanned is small, and the number of items to be temporarily retained is low, a limited-capacity, short-term store is sufficient to allow associations to be formed. Such a store is presumed to operate in parallel with the hippocampus in normal animals. Hippocampal damage disrupts a much higher-capacity store that has a slower decay rate, and so leaves animals with only a very limited ability to form temporally discontiguous associations. Hippocampal damage, however, is not held to affect the long-term storage of associations of any kind, if they can be formed. Analyses of both new and existing data are presented to show that by classifying tasks in terms of the need to use a temporary memory store to retain temporally discontiguous information one can cut right across existing classifications as well as achieve a better fit to the data. The hippocampus thus seems best described as a high-capacity, intermediate-term memory store. (shrink)

International array of contributors, bringing together both traditional and more recent approaches to provide valuable insights into the poets’ use of language.Covers authors from Lucilius to Juvenal.Of the peoples of ancient Italy, only the Romans committed newly composed poems to writing, and for 250 years Latin-speakers developed an impressive verse literature.The language had traditional resources of high style, e.g., alliteration, lexical and morphological archaism or grecism, and of course metaphor and word order; and there were also less obvious resources in (...) the technical vocabularies of law, philosophy and medicine.The essays in this volume show how the poets in the classical period combined these elements, and so created a poetic medium that could comprehend satire, invective, erotic elegy, drama, lyric, and the grandest heroic epos. (shrink)

The degrees of formality into which speech can be graded are in no sphere more obvious than in expressions of address and third-person reference. Methods of naming vary according to many factors: the formality of the circumstances in which naming takes place, the nature of the subject under discussion, and the ages, sex, and relative status of the speaker and addressee. Conventions of naming sometimes reflect the rigidity or otherwise of social divisions. In some societies or circles address between superior (...) and subordinate is non-reciprocal: the speaker with the greater prestige will adopt one form of address, the subordinate another. In other societies when unequals address each other both may use the same formal method of address: the difference of prestige is not explicitly acknowledged. (shrink)

Renowned philosopher J. N. Mohanty examines the range of Indian philosophy from the Sutra period through the 17th century Navya Nyaya. Instead of concentrating on the different systems, he focuses on the major concepts and problems dealt with in Indian philosophy. The book includes discussions of Indian ethics and social philosophy, as well as of Indian law and aesthetics.

It would be a mistake to attempt to identify in modern terms the disease of Galerius described so graphically by Lactantius, Mort. 33. Consumption by lice or worms, if not genital ‘gangrene’, was a typical end for a tyrant or the impious, and there must be an element of literary exaggeration in Lactantius' account. But whatever one makes of the nature of the illness, Lactantius did set out to give the passage a scientific plausibility by his use of technical medical (...) phraseology, and by an allusion to a medical theory at 33.7. Recognition of this theory allows one to settle the text at one point, where editors have failed to agree. There is also a second place in the chapter where familiarity with medical Latin points one towards the solution of a textual problem. (shrink)

Professor Findlay in this book, originally published in 1961, set out to justify, and to some extent carry out, a ‘material value-ethic’, ie. A systematic setting forth of the ends of rational action. The book is in the tradition of Moore, Rashfall, Ross, Scheler and Hartmann though it avoids altogether dogmatic intuitive methods. It argues that an organised framework of ends of action follows from the attitude underlying our moral pronouncements, and that this framework, while allowing personal elaboration, is not (...) a matter for individual decision. The relations connecting our fundamental value-judgements with one another, and the frames of mind behind them, are not rigorously deductive but are sufficiently compelling to be called logical. Something of a ‘transcendental deduction’ of a well-ordered family for our basic heads of valuation is both possible and necessary. The work is further critical of the notion of obligation which has been extended far beyond legal contracts and understandings. The book also contains a chapter on religion. (shrink)

The degrees of formality into which speech can be graded are in no sphere more obvious than in expressions of address and third-person reference. Methods of naming vary according to many factors: the formality of the circumstances in which naming takes place, the nature of the subject under discussion, and the ages, sex, and relative status of the speaker and addressee. Conventions of naming sometimes reflect the rigidity or otherwise of social divisions. In some societies or circles address between superior (...) and subordinate is non-reciprocal: the speaker with the greater prestige will adopt one form of address, the subordinate another. In other societies when unequals address each other both may use the same formal method of address: the difference of prestige is not explicitly acknowledged. (shrink)

The text of the fourth-century veterinary writer Pelagonius, recently edited for the first time this century and greatly improved by K.-D. Fischer, poses many problems for an editor. The Latinity of Pelagonius himself in the epistles which precede various chapters is awkward and difficult to understand. Much of the rest of the work is a compilation, not all of it Pelagonius' own work, based on a variety of sources from the magical to the scientific. The work survives largely in a (...) single manuscript, codex Riccardianus 1179, a. 1485 . In this paper I pass over intractable questions of spelling and concentrate on more substantial problems of text and interpretation, some of which concern punctuation. (shrink)

The text of the fourth-century veterinary writer Pelagonius, recently edited for the first time this century and greatly improved by K.-D. Fischer, poses many problems for an editor. The Latinity of Pelagonius himself in the epistles which precede various chapters is awkward and difficult to understand. Much of the rest of the work is a compilation, not all of it Pelagonius' own work, based on a variety of sources from the magical to the scientific. The work survives largely in a (...) single manuscript, codex Riccardianus 1179, a. 1485. In this paper I pass over intractable questions of spelling and concentrate on more substantial problems of text and interpretation, some of which concern punctuation. (shrink)

The Ars Veterinaria of the fourth-century writer Pelagonius has hitherto been known only from the MS. Florence, Bibl. Riccardiana 1179 , a codex copied in 1485 for Politian from an early manuscript. Apart from this there have only been some palimpsest fragments from Bobbio.

TheArs Veterinariaof the fourth-century writer Pelagonius has hitherto been known only from the MS.Florence, Bibl. Riccardiana1179 (R), a codex copied in 1485 for Politian from an early (lost) manuscript. Apart from this there have only been some palimpsest fragments from Bobbio.

Although the biographies known collectively as the Historia Augusta purport to have been written by six different biographers, it has often been thought that their similarities are so numerous that they must be the work of a single author. In this article I shall deal with a piece of linguistic evidence which supports this view. The two scholars who have treated the language of the H.A. in most detail, E. Wölfnin and E. Klebs, attempted to show that certain linguistic features (...) which are not spread evenly among the Scriptores point to multiplicity of authorship. (shrink)

Although the biographies known collectively as theHistoria Augustapurport to have been written by six different biographers, it has often been thought that their similarities are so numerous that they must be the work of a single author. In this article I shall deal with a piece of linguistic evidence which supports this view.The two scholars who have treated the language of theH.A.in most detail, E. Wölfnin and E. Klebs, attempted to show that certain linguistic features which are not spread evenly (...) among the Scriptores point to multiplicity of authorship. (shrink)

It is well known that mitto comes to mean ‘put’ in late Latin and that it shows reflexes with this sense in the Romance languages . But the nature of this semantic change has not been fully explained, nor has the relationship of the word with other placing-terms in Latin. E. Löfstedt has stated simply that it ‘takes over the meaning ot ponere’.2 But as pono itself remains common in all types of Latin, the question arises whether the two words (...) did really come into conflict. It is the purpose of the first two sections of this article to show that for a considerable period pono and mitto occupied complementary places in a lexical system. This system exhibits a definite structure which remains unaltered from early Latin to at least the sixth century A.D., though its component terms undergo some changes. In section I pono and the words which in earlier Latin performed the functions later assumed by mitto will be discussed. In section I I we shall move on to mitto itself. It will be necessary to consider the nature and motivation of the transition ‘throwput’ as it appears in Latin. (shrink)

It is well known that mitto comes to mean ‘put’ in late Latin and that it shows reflexes with this sense in the Romance languages. But the nature of this semantic change has not been fully explained, nor has the relationship of the word with other placing-terms in Latin. E. Löfstedt has stated simply that it ‘takes over the meaning ot ponere’.2 But as pono itself remains common in all types of Latin, the question arises whether the two words did (...) really come into conflict. It is the purpose of the first two sections of this article to show that for a considerable period pono and mitto occupied complementary places in a lexical system. This system exhibits a definite structure which remains unaltered from early Latin to at least the sixth century A.D., though its component terms undergo some changes. In section I pono and the words which in earlier Latin performed the functions later assumed by mitto will be discussed. In section I I we shall move on to mitto itself. It will be necessary to consider the nature and motivation of the transition ‘throwput’ as it appears in Latin. (shrink)